反应详情

To a solution of 3,5-dimethoxy-pyrazine-2-carbaldehyde (120 mg, 0.71 mmol) in MeOH (8 mL) is added sodium borohydride (40 mg, 1.1 mmol) at 0° C. After the mixture is stirred at this temperature for 0.5 hour, the reaction is quenched with saturated NH4Cl (0.7 mL) and solvent removed in vacuo until dryness. DCM (20 mL) is added, and the solution is dried and solvent removed to give 118 mg of (3,5-dimethoxy-pyrazin-2-yl)-methanol as an oil.

1. customthe reaction is quenched with saturated NH4Cl (0.7 mL) and solvent
2. customremoved in vacuo until dryness
3. additionDCM (20 mL) is added
4. customthe solution is dried
5. customsolvent removed