Ethyl 2-(4-hydroxyphenoxy)-2-methylpropanoate → HCID 74067278, compound

HRID 1609917Notes

Reaction equation

HRID 1609917 reaction equation
[CH3:1][C:2]1[O:6][C:5]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)=[N:4][C:3]=1[CH:13]=[CH:14][CH2:15][OH:16].O[C:18]1[CH:32]=[CH:31][C:21]([O:22][C:23]([CH3:30])([CH3:29])[C:24]([O:26][CH2:27][CH3:28])=[O:25])=[CH:20][CH:19]=1>>[CH3:30][C:23]([O:22][C:21]1[CH:20]=[CH:19][C:18]([O:16][CH2:15][CH:14]=[CH:13][C:3]2[N:4]=[C:5]([C:7]3[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=3)[O:6][C:2]=2[CH3:1])=[CH:32][CH:31]=1)([CH3:29])[C:24]([O:26][CH2:27][CH3:28])=[O:25]

Participants

3

Reactant 2

HCID 181741Ethyl 2-(4-hydroxyphenoxy)-2-methylpropanoateHCID 69310779HCID 69310779, compound

Product 1

HCID 74067278HCID 74067278, compound

Procedure

Synthesized from 3-(5-methyl-2-phenyloxazol-4-yl)-prop-2-en-1-ol and ethyl 2-(4-hydroxyphenoxy)-2-methylpropanoate (American Home Products, U.S. Pat. No. 3,795,691) via an analogous procedure to that reported for Example 2, Step A: 1H NMR (300 MHz, CDCl3) δ 7.95-7.99 (m, 2H), 7.36-7.43 (m, 3H), 6.80 (s, 4H), 6.61 (dt, 1H), 6.49 (d, 1H), 4.62 (d, 2H), 4.18 (q, 2H), 2.37 (s, 3H), 1.49 (s, 6H), 1.23 (t, 3H); MS (EI): 422 (M+1).

Sources & evidence

ORD record
ord-566d25d259fa42e3b6eb595996e9ff0e
Source dataset
uspto-grants-2006_01
Patent number
US06982278B2

Reaction notes

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