2-(5-Methyl-2-phenyloxazol-4-yl)ethyl 4-methylbenzenesulfonate → HCID 69315861, compound

HRID 1609948Notes

Reaction equation

HRID 1609948 reaction equation
[CH2:1]([O:3][C:4](=[O:15])[CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([OH:13])=[CH:9][C:8]=1[CH3:14])[CH3:2].[CH3:16][C:17]1[O:21][C:20]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)=[N:19][C:18]=1[CH2:28][CH2:29]OS(C1C=CC(C)=CC=1)(=O)=O>>[CH2:1]([O:3][C:4](=[O:15])[CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:29][CH2:28][C:18]2[N:19]=[C:20]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)[O:21][C:17]=2[CH3:16])=[CH:9][C:8]=1[CH3:14])[CH3:2]

Participants

3

Reactant 2

HCID 120517392-(5-Methyl-2-phenyloxazol-4-yl)ethyl 4-methylbenzenesulfonateHCID 21986458Ethyl (4-hydroxy-2-methylphenoxy)acetate

Product 1

HCID 69315861HCID 69315861, compound

Procedure

(4-Hydroxy-2-methylphenoxy) acetic acid ethyl ester and toluene-4-sulfonic acid 2-(5-methyl-2-phenyl-oxazol-4-yl)ethyl ester were coupled as described in Example 24, Step C. 1H NMR (400 MHz, CDCl3) δ 1.28 (t, 3H, J=7.0 Hz), 2.25 (s, 3H), 2.36 (s, 3H), 2.94 (t, 2H, J=6.8 Hz), 4.17 (t, 2H, J=6.6 Hz), 4.23 (q, 2H, J=7.0 Hz), 4.55 (s, 2H), 6.65 (s, 2H), 6.72 (s, 1H), 7.38-7.44 (m, 3H), 7.94-7.97 (m, 2H); MS (ES) m/e 396.2 (M+1).

Sources & evidence

ORD record
ord-ac832cb1d1d442b29e5d566102695ba6
Source dataset
uspto-grants-2006_01
Patent number
US06982278B2

Reaction notes

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