反应详情

A mixture of 2-allyl-4-benzyloxy-phenol (ER2-YYR-17) (35.56 g, 148 mmol), allyl bromide (21.5 g, 178 mmol), cesium carbonate (58 g, 178 mmol) and methyl ethyl ketone (400 mL) was refluxed with stirring in a 1 L round bottomed flask. After 23 h, the reaction was cooled and concentrated. The residue was partitioned between water (500 mL) and EtOAc (400 mL). The organic layer was dried (MgSO4) and concentrated to a tan oil, 39.37 (95%) ER0-LKW-190A: 1H NMR (CDCl3) δ 3.45 (dd, 2H), 4.54 (dd, 2H), 5.04 (s, 2H), 5.18 (m, 2H), 5.29 (dd, 1H), 5.46 (dd, 1H), 5.94-6.18 (m, 2H), 6.81 (s, 2H), 6.88 (s, 1H), 7.30-7.48 (m, 5H), MS (ES) m/e 281 [M+1].

1. temperaturewas refluxed
2. temperaturethe reaction was cooled
3. concentrationconcentrated
4. customThe residue was partitioned between water (500 mL) and EtOAc (400 mL)
5. dry with materialThe organic layer was dried (MgSO4)
6. concentrationconcentrated to a tan oil, 39.37 (95%)