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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1610029Generated: October 30, 2026

Isopropanol → isopropyl-2-(2,4-dimethoxyphenyl)-4,5-dihydro-thiazole-4-(R)-carboxylate

https://huagongshe.com/reaction/1610029

Reaction equation

Participants

RoleNameHCIDCharge
ReactantIsopropanolHCID 3776—
ReactantDicyclohexylcarbodiimideHCID 10868—
Reactant2-(2,4-dimethoxyphenyl)-4,5-dihydro-thiazole-4-(R)-carboxylic acidHCID 17747725—
Catalyst4-(Dimethylamino)pyridineHCID 14284—
SolventTetrahydrofuranHCID 8028—
Productisopropyl-2-(2,4-dimethoxyphenyl)-4,5-dihydro-thiazole-4-(R)-carboxylateHCID 17747726—

Reaction Steps

Next, 2-(2,4-dimethoxyphenyl)-4,5-dihydro-thiazole-4-(R)-carboxylic acid is reacted with isopropanol; DCC; and 4-(dimethylamino)pyridine (DMAP) in tetrahydrofuran (THF) at room temperature to form isopropyl-2-(2,4-dimethoxyphenyl)-4,5-dihydro-thiazole-4-(R)-carboxylate.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06982335B2
Source datasetuspto-grants-2006_01
ORD IDord-831aabc54ef848699c10ea320e3a045b
Source noteuspto-grants-2006_01