HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrazine → 4-(4-Phenylpiperazin-1-YL)butan-1-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrazine | HCID 9321 | — |
| Reactant | 2-[4-(4-phenylpiperazin-1-yl)butyl]-2,3-dihydro-1H-isoindole-1,3-dione | HCID 600461 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 4-(4-Phenylpiperazin-1-YL)butan-1-amine | HCID 14162478 | — |
Reaction Steps
Compound 3b (7.70 g, 21.21 mmol) was reacted with NH2NH2 (3.0 g, 93.75 mmol) in EtOH (60 mL) to give 4b, 4.60 g (93%) (Procedure B). 1H NMR (CDCl3) 1.48-1.61 (m, 4H), 2.83-2.43 (t, J=7.2 Hz, 2H, NCH2), 2.61-2.63 (t, J=4.5 Hz, 4H, N(CH2)2), 2.72-2.76 (t, J=6.4 Hz, 2H, NCH2), 3.19-3.22 (t, J=4.6 Hz, 4H, N(CH2)2), 6.33-6.94 (m, 3H, Ar—H), 7.23-7.28 (m, 2H, Ar—H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06982332B2 |
| Source dataset | uspto-grants-2006_01 |
| ORD ID | ord-ccb71017986142b09cc338e918609838 |
| Source note | uspto-grants-2006_01 |