Formaldehyde → 1-Butanamine, N-butyl-N-methyl-

HRID 1610047Notes

Reaction equation

HRID 1610047 reaction equation
[CH2:1]([NH:5][CH2:6][CH2:7][CH2:8][CH3:9])[CH2:2][CH2:3][CH3:4].[CH2:10]=O>>[CH3:10][N:5]([CH2:6][CH2:7][CH2:8][CH3:9])[CH2:1][CH2:2][CH2:3][CH3:4]

Participants

3

Reactant 2

HCID 712FormaldehydeHCID 8148Dibutylamine

Product 1

HCID 188551-Butanamine, N-butyl-N-methyl-Yield 95.8%

Procedure

In a similar manner to Example 1, 258.5 g (2.0 mol) of di-n-butylamine and 330.2 g (3.2 mol) of formaldehyde (29.1%) are reacted in a 1 l autoclave; a maximum pressure of 3.2 MPa is established at a temperature of 120° C. After the crude amine (aqueous and organic phase) has been degassed at a maximum temperature of 80° C., the water is removed on a water separator. The remaining organic phase is subsequently fractionally distilled. 274.6 g of N-methyldi-n-butylamine having a purity of 99.6% are isolated, corresponding to a yield of 95.6% of theory.

Workup

  1. customis established at a temperature of 120° C
  2. customAfter the crude amine (aqueous and organic phase) has been degassed at a maximum temperature of 80° C.
  3. customthe water is removed on a water separator
  4. distillationThe remaining organic phase is subsequently fractionally distilled

Sources & evidence

ORD record
ord-83ecc5200c54442981c68e3a50747494
Source dataset
uspto-grants-2006_01
Patent number
US06982352B2

Reaction notes

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