Formaldehyde → HCID 12137753, compound

HRID 1610048Notes

Reaction equation

HRID 1610048 reaction equation
[CH2:1]([NH:3][CH:4]([CH3:8])[CH:5]([CH3:7])[CH3:6])[CH3:2].[CH2:9]=O>>[CH3:9][N:3]([CH:4]([CH3:8])[CH:5]([CH3:7])[CH3:6])[CH2:1][CH3:2]

Participants

3

Reactant 2

HCID 712FormaldehydeHCID 1028732-Butanamine, N-ethyl-3-methyl-

Product 1

HCID 12137753HCID 12137753, compoundYield 97.4%

Procedure

In a similar manner to Example 1, 230.4 g (2.0 mol) of N-ethyl-1,2-dimethylpropylamine and 330.2 g (3.2 mol) of formaldehyde (29.1%) are reacted in a 1 l autoclave; a maximum pressure of 2.3 MPa is established at a temperature of 120° C. After the crude amine (aqueous and organic phase) has been degassed at a maximum temperature of 94° C., the water is removed on a water separator. The remaining organic phase is subsequently fractionally distilled. 251.7 g of N-methyl-N-ethyl-1,2-dimethylpropylamine having a purity of 98.6% are isolated, corresponding to a yield of 96.0% of theory.

Workup

  1. customis established at a temperature of 120° C
  2. customAfter the crude amine (aqueous and organic phase) has been degassed at a maximum temperature of 94° C.
  3. customthe water is removed on a water separator
  4. distillationThe remaining organic phase is subsequently fractionally distilled

Sources & evidence

ORD record
ord-93fcd24482674e95a40c74cae7e17a3b
Source dataset
uspto-grants-2006_01
Patent number
US06982352B2

Reaction notes

Loading…