HCID 22261030, compound → HCID 22260751, compound

HRID 1610107Notes

Reaction equation

HRID 1610107 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:8]2[C:16]3[C:11](=[CH:12][CH:13]=[C:14]([C:17]([C:19]4[S:20][CH:21]=[CH:22][CH:23]=4)=[O:18])[CH:15]=3)[N:10](CO)[N:9]=2)[CH:5]=[CH:6][CH:7]=1>CO>[NH3:9].[F:1][C:2]1[CH:3]=[C:4]([C:8]2[C:16]3[C:11](=[CH:12][CH:13]=[C:14]([C:17]([C:19]4[S:20][CH:21]=[CH:22][CH:23]=4)=[O:18])[CH:15]=3)[NH:10][N:9]=2)[CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 1

HCID 22261030HCID 22261030, compound

Product 2

HCID 222AmmoniaHCID 22260751HCID 22260751, compoundYield 141.5%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

By treating 17 mg of [3-(3-fluorophenyl)-1-(hydroxymethyl)-1H-5-indazolyl](2-thienyl)methanone, a by-product formed by incomplete deprotection in the above reaction, with concentrated aqueous ammonia solution in methanol, 11 mg of the title compound was further obtained.

Sources & evidence

ORD record
ord-e63a8ffff06b47ed9a540fc5f34c13aa
Source dataset
uspto-grants-2006_01
Patent number
US06982274B2

Reaction notes

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