Acetic Acid → HCID 178427219, compound

HRID 1610131Notes

Reaction equation

HRID 1610131 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:8]2[C:16]3[C:11](=[C:12]([CH3:19])[CH:13]=C(C#N)[CH:15]=3)[NH:10][N:9]=2)[CH:5]=[CH:6][CH:7]=1.[C:20]([OH:23])(=[O:22])[CH3:21].S(=O)(=O)(O)O>O>[F:1][C:2]1[CH:3]=[C:4]([C:8]2[C:16]3[C:11](=[C:12]([CH3:19])[CH:13]=[C:21]([C:20]([OH:23])=[O:22])[CH:15]=3)[NH:10][N:9]=2)[CH:5]=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 1118Sulfuric AcidHCID 178426383HCID 178426383, compound

Product 1

HCID 178427219HCID 178427219, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Conditions

Temperature
100 °C

Procedure

To 430 mg of 3-(3-fluorophenyl)-7-methyl-1H-indazole-5-carbonitrile were sequentially added 6.0 ml of glacial acetic acid, 2.0 ml of water and 2.0 ml of concentrated sulfuric acid, followed by stirring at 100° C. for one day. After standing to cool, the reaction mixture was diluted with 20 ml of water, and the resulting crystals were collected by filtration. The crystals were sequentially washed with water and diethyl ether, to give 360 mg of the title compound as colorless crystals.

Workup

  1. temperatureto cool
  2. filtrationthe resulting crystals were collected by filtration
  3. washThe crystals were sequentially washed with water and diethyl ether

Sources & evidence

ORD record
ord-16d01bdb98634507812296c8cb09b12d
Source dataset
uspto-grants-2006_01
Patent number
US06982274B2

Reaction notes

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