Acetic Acid → HCID 178524525, compound

HRID 1610155Notes

Reaction equation

HRID 1610155 reaction equation
[F:1][C:2]1[CH:3]=C(C#N)[CH:5]=[C:6]2[C:10]=1[NH:9][N:8]=[C:7]2[C:11]1[CH:20]=[CH:19][C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[CH:12]=1.[C:23]([OH:26])(=[O:25])[CH3:24].S(=O)(=O)(O)O>O>[F:1][C:2]1[CH:3]=[C:24]([C:23]([OH:26])=[O:25])[CH:5]=[C:6]2[C:10]=1[NH:9][N:8]=[C:7]2[C:11]1[CH:20]=[CH:19][C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[CH:12]=1

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 1118Sulfuric AcidHCID 178510115HCID 178510115, compound

Product 1

HCID 178524525HCID 178524525, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Conditions

Temperature
120 °C

Procedure

To 1.0 g of 7-fluoro-3-naphthalen-2-yl-1H-indazole-5-carbonitrile were sequentially added 5.0 ml of glacial acetic acid, 5.0 ml of water and 10.0 ml of concentrated sulfuric acid, and the mixture was stirred at 120° C. for one day. After standing to cool, 20 ml of water was added to the reaction mixture and the resulting crystals were collected by filtration. The crystals were sequentially washed with water and diethyl ether, to give 1.0 g of the title compound as colorless crystals.

Workup

  1. temperatureto cool
  2. filtrationthe resulting crystals were collected by filtration
  3. washThe crystals were sequentially washed with water and diethyl ether

Sources & evidence

ORD record
ord-242fbf3254f149d0acf26aadbff5a7d9
Source dataset
uspto-grants-2006_01
Patent number
US06982274B2

Reaction notes

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