反应详情

To a solution of ethyl (2RS,3SR)-3-(4-fluorophenyl)-3-hydroxy-2-((4-(trifluoromethyl)phenyl)methyl)propionate (4.85 g, 13.1 mmol) in methanol (20 ml) was added 1N aqueous sodium hydroxide solution (13.1 ml, 13.1 mmol), and the mixture was stirred at room temperature for 6 hrs. The reaction solution was evaporated under reduced pressure, diluted with 1N hydrochloric acid (50 ml), and extracted with ethyl acetate (100 ml×2). The extract was washed with water and saturated brine, dried over anhydrous magnesium sulfate and evaporated under reduced pressure. The residue was recrystallized from ethyl acetate-hexane to give (2RS,3SR)-3-(4-fluorophenyl)-3-hydroxy-2-((4-(trifluoromethyl)phenyl)methyl)propionic acid (3.8 g, 84%).

1. customThe reaction solution was evaporated under reduced pressure
2. additiondiluted with 1N hydrochloric acid (50 ml)
3. extractionextracted with ethyl acetate (100 ml×2)
4. washThe extract was washed with water and saturated brine
5. dry with materialdried over anhydrous magnesium sulfate
6. customevaporated under reduced pressure
7. customThe residue was recrystallized from ethyl acetate-hexane