反应详情

To a solution of 1,1-dimethylethyl (1RS,2SR)-2-(4-fluorophenyl)-2-hydroxy-1-((4-(trifluoromethyl)phenyl)methyl)ethylcarbamate (2.58 g, 6.24 mmol) in ethanol (35 ml) was. added 20% hydrogen chloride ethanol solution (35 ml) and the mixture was heated under reflux for 30 min. The reaction solution was evaporated under reduced pressure and the residue was washed with diethyl ether. to give (1RS,2SR)-1-(4-fluorophenyl)-1-hydroxy-3-(4-(trifluoromethyl)phenyl)-2-propylamine hydrochloride (2.05 g, 94%).

1. temperaturethe mixture was heated
2. temperatureunder reflux for 30 min
3. customThe reaction solution was evaporated under reduced pressure
4. washthe residue was washed with diethyl ether