反应详情

To absolution of 3-fluoro-4-(trifluoromethyl)benzyl alcohol (10 g, 52 mmol) in chloroform (20 ml) was added thionyl chloride (18.5 ml, 257 mmol) and the mixture was heated under ref lux for 4 hrs. The reaction solution was concentrated. The residue was purified by silica gel column chromatography (hexane:ethyl acetate=4:1) to give 3-fluoro-4-(trifluoromethyl)benzyl chloride (9.52 g, 87%).

1. temperaturethe mixture was heated under ref lux for 4 hrs
2. concentrationThe reaction solution was concentrated
3. customThe residue was purified by silica gel column chromatography (hexane:ethyl acetate=4:1)