Sodium Hydroxide → HCID 22262173, compound

Participants

Reaction Steps

To a solution of (4RS,5SR)-5-(4-fluorophenyl)-4-((4-(phenyloxy)phenyl)methyl)-1,3-oxazolidin-2-one (2.5 g, 6.88 mmol) in ethanol (20 ml) was added 8N aqueous sodium hydroxide solution (4.30 ml, 34.4 mmol) and the mixture was heated under reflux for 6 hrs. The reaction solution was concentrated, diluted with water (100 ml) and extracted with ethyl acetate (100 ml×2). The extract was washed with saturated brine, dried over anhydrous magnesium sulfate and evaporated under reduced pressure to give (1RS,2SR)-2-amino-1-(4-fluorophenyl)-3-(4-(phenyloxy)phenyl)-1-propanol (2.2 g, 95%).

Provenance & Evidence