HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Methyl-2-(trifluoromethyl)-3-furancarboxylic acid → 2-Methyl-5-(trifluoromethyl)furan
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Methyl-2-(trifluoromethyl)-3-furancarboxylic acid | HCID 2782183 | — |
| Catalyst | Sulfuric acid, copper(1+) salt (1:2) | HCID 134737 | — |
| Solvent | Quinoline | HCID 7047 | — |
| Product | 2-Methyl-5-(trifluoromethyl)furan | HCID 10953688 | 54% |
Reaction Steps
To a solution of 5-methyl-2-(trifluoromethyl)-3-furancarboxylic acid (20 g, 103 mmol) in quinoline (36 ml) was added copper (I) sulfate (1 g, 6.3 mmol). While bubbling nitrogen, the mixture was immersed in an oil bath at 230° C. until gas generation ceased. The generated gas was collected and distilled again to give 2-methyl-5-(trifluoromethyl)furan (8.34 g, 54%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06982348B2 |
| Source dataset | uspto-grants-2006_01 |
| ORD ID | ord-1ad3a181e7444430b968eb54d685f291 |
| Source note | uspto-grants-2006_01 |