Trifluoroacetic acid → HCID 22262071, compound

Participants

Reaction Steps

To 1,1-dimethylethyl (1RS,2SR)-2-hydroxy-2-(4-pyridyl)-1-((4-(trifluoromethyl)phenyl)methyl)ethylcarbamate (300 mg, 0.76 mmol) was added trifluoroacetic acid (3 ml), and the mixture was stirred at room temperature for 10 min. To the reaction solution was added 1N aqueous sodium hydroxide solution (10 ml) and the mixture was extracted with ethyl acetate (20 ml×2). The extract was washed with saturated brine, dried over anhydrous magnesium sulfate and evaporated under reduced pressure. The residue was recrystallized from ethyl acetate-diisopropyl ether to give (1RS,2SR)-2-amino-1-(4-pyridyl)-3-(4-(trifluoromethyl)phenyl)-1-propanol (135 mg, 60%).

Provenance & Evidence