Thionyl Chloride → Enzalutamide Impurity 20

HRID 161044Notes

Reaction equation

HRID 161044 reaction equation
[C:1](#[N:2])[c:3]1[c:4]([C:28]([F:29])([F:30])[F:31])[cH:5][c:6]([N:9]2[C:10](=[S:27])[N:11]([c:17]3[cH:18][c:19]([F:26])[c:20]([C:21](=[O:22])[OH:23])[cH:24][cH:25]3)[C:12]([CH3:15])([CH3:16])[C:13]2=[O:14])[cH:7][cH:8]1.[S:32](=[O:33])([Cl:34])[Cl:35]>>[C:1](#[N:2])[c:3]1[c:4]([C:28]([F:29])([F:30])[F:31])[cH:5][c:6]([N:9]2[C:10](=[O:33])[N:11]([c:17]3[cH:18][c:19]([F:26])[c:20]([C:21](=[O:22])[OH:23])[cH:24][cH:25]3)[C:12]([CH3:15])([CH3:16])[C:13]2=[O:14])[cH:7][cH:8]1

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 46898522Enzalutamide carboxylic acid

Product 1

HCID 46898525Enzalutamide Impurity 20

Sources & evidence

ORD record
ord-93b9ebc4e1a447578ef5314cd14ad5c6
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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