Hydrochloric Acid → HCID 17862246, compound

Participants

Reaction Steps

To a solution of ethyl(2RS,3RS)-3-(3-fluorophenyl)-3-hydroxy-2-[3-(1,1,2,2-tetrafluoroethoxy)benzyl]propanoate (6.92 g, 16.5 mmol) in methanol (50 ml) was added 2N aqueous sodium hydroxide solution (16.5 ml, 33.0 mmol), and the mixture was stirred at room temperature for 2 hrs. The reaction solution was acidified with 1N hydrochloric acid and extracted with ethyl acetate (200 ml×2). The extract was washed with water and saturated brine, dried (anhydrous magnesium sulfate) and evaporated under reduced pressure. Recrystallization of the residue from ethyl acetate-hexane gave the objective substance (4.28 g, 66%).

Provenance & Evidence