Hydrochloric Acid → HCID 22261577, compound

Participants

Reaction Steps

To a solution of ethyl (2RS,3RS)-3-(4-fluorophenyl)-3-hydroxy-2-{[6-(1,1,2,2-tetrafluoroethoxy)pyridin-2-yl]methyl}propanoate (1.28 g, 3.05 mmol) in methanol (6 ml) was added 2N aqueous sodium hydroxide solution (3.05 ml, 6.1 mmol), and the mixture was stirred overnight at room temperature. The reaction solution was acidified with 1N hydrochloric acid, saturated aqueous sodium hydrogen carbonate was added and the mixture was extracted with ethyl acetate (50 ml×2). The extract was washed with water and saturated brine, dried (anhydrous magnesium sulfate) and evaporated under reduced pressure to give the objective substance (1.20 g, 100%).

Provenance & Evidence