Hydrochloric Acid → HCID 22261852, compound

Participants

Reaction Steps

To a solution of ethyl (2RS,3RS)-3-[3-(benzyloxy)phenyl]-3-hydroxy-2-[3-(1,1,2,2-tetrafluoroethoxy)benzyl]propanoate (10.7 g, 21.2 mmol, crude) in methanol (50 ml) was added. 2N aqueous sodium hydroxide solution (21 ml, 42 mmol), and the mixture was stirred overnight at room temperature. The reaction solution was acidified with 1N hydrochloric acid and extracted with ethyl acetate (50 ml×2). The extract was washed with water and saturated brine, dried (anhydrous magnesium sulfate) and evaporated under reduced pressure. The obtained crude crystals were washed with hexane to give the objective substance (7.90 g, 49% in 3 steps).

Provenance & Evidence