Sodium Hydroxide → HCID 22261569, compound

Participants

Reaction Steps

To a solution of (4RS,5SR)-5-[3-(benzyloxy)phenyl]-4-[3-(1,1,2,2-tetrafluoroethoxy)benzyl]-1,3-oxazolidin-2-one (6.5 g, 13.7 mmol) in ethanol (70 ml) was added 8N aqueous sodium hydroxide solution (5.13 ml, 41 mmol), and the mixture was heated under reflux for 4 hrs. The reaction solution was concentrated, diluted with water (100 ml) and extracted with ethyl acetate (100 ml×2). The extract was washed with saturated brine, dried (anhydrous magnesium sulfate) and evaporated under reduced pressure to give the objective substance (6.26 g, 100%).

Provenance & Evidence