反应详情

温度

80 °C

To a solution of benzyl 4-(pyridin-3-yloxy)benzoate (18.0 g, 5.90 mmol) in ethanol (300 ml) was added 10% palladium/carbon (containing water by 50%, 2.0 g), and the mixture was stirred under a hydrogen stream at 80° C. overnight. The reaction solution was filtered with celite and the filtrate was concentrated. The residue was recrystallized from ethanol-hexane to give the objective substance (11.2 g, 88%).

1. filtrationThe reaction solution was filtered with celite
2. concentrationthe filtrate was concentrated
3. customThe residue was recrystallized from ethanol-hexane
4. customto give the objective substance (11.2 g, 88%)