HCID 86593277, compound → HCID 22261695, compound

Participants

Reaction Steps

To a solution of benzyl (2RS,3RS)-3-hydroxy-3-[4-(pyridin-3-yloxy)phenyl]-2-[3-(1,1,2,2-tetrafluoroethoxy)benzyl]propanoate (3.00 g, 5.38 mmol) in ethanol (200 ml) was added 10% palladium/carbon (containing water by 50%, 300 mg), and the mixture was stirred under a 1 atm hydrogen stream for 1 hr. The reaction solution was filtered with celite and the filtrate was concentrated to give the objective substance (2.8 g, 100%, crude). The present compound was used for, the next reaction as a crude compound.

Provenance & Evidence