反应详情

温度

80 °C

To a solution of (4RS,5SR)-4-(4-tert-butylbenzyl)-5-(3-chlorophenyl)-1,3-oxazolidin-2-one (9.50 g, 27.6 mmol) in ethanol (70 ml) was added 8N aqueous sodium hydroxide solution (17.3 ml, 138 mmol), and the mixture was stirred at 80° C. overnight. To the reaction solution was added water (20 ml) and the mixture was extracted with ethyl acetate (50 ml×2). The extract was washed with water and saturated brine, dried (anhydrous magnesium sulfate) and evaporated under reduced pressure to give the objective substance (8.82 g, 100%).

1. extractionthe mixture was extracted with ethyl acetate (50 ml×2)
2. washThe extract was washed with water and saturated brine
3. dry with materialdried (anhydrous magnesium sulfate)
4. customevaporated under reduced pressure
5. customto give the objective substance (8.82 g, 100%)