Water → (1RS,2SR)-2-amino-3-(4-tert-butoxyphenyl)-1-(3-chlorophenyl)propan-1-ol

HRID 1610634Notes

Reaction equation

[C:1]([O:5][C:6]1[CH:25]=[CH:24][C:9]([CH2:10][CH:11]2[CH:15]([C:16]3[CH:21]=[CH:20][CH:19]=[C:18]([Cl:22])[CH:17]=3)[O:14]C(=O)[NH:12]2)=[CH:8][CH:7]=1)([CH3:4])([CH3:3])[CH3:2].[OH-].[Na+].O>C(O)C>[NH2:12][CH:11]([CH2:10][C:9]1[CH:8]=[CH:7][C:6]([O:5][C:1]([CH3:4])([CH3:3])[CH3:2])=[CH:25][CH:24]=1)[CH:15]([C:16]1[CH:21]=[CH:20][CH:19]=[C:18]([Cl:22])[CH:17]=1)[OH:14]

Participants

Conditions

Temperature: 80 °C

Procedure

To a solution of (4RS,5SR)-4-(4-tert-butoxybenzyl)-5-(3-chlorophenyl)-1,3-oxazolidin-2-one (3.80 g, 10.6 mmol) in ethanol (20 ml) was added 8N aqueous sodium hydroxide solution (3.96 ml, 31.7 mmol), and the mixture was stirred at 80° C. for 6 hrs. To the reaction solution was added water (20 ml) and the mixture was extracted with ethyl acetate (50 ml×2). The extract was washed with water and saturated brine, dried (anhydrous magnesium sulfate) and evaporated under reduced pressure. The residue was recrystallized from hexane-ethyl acetate to give the objective substance (2.67 g, 76%).

Workup

extractionthe mixture was extracted with ethyl acetate (50 ml×2)
washThe extract was washed with water and saturated brine
dry with materialdried (anhydrous magnesium sulfate)
customevaporated under reduced pressure
customThe residue was recrystallized from hexane-ethyl acetate
customto give the objective substance (2.67 g, 76%)

Sources & evidence

ORD record: ord-18fd88d2019e41b18d820133f4a35f18
Source dataset: uspto-grants-2006_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06982348B2

Reaction notes

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