反应详情

温度

80 °C

To a solution of (4RS,5SR)-4-(4-tert-butoxybenzyl)-5-(3-chlorophenyl)-1,3-oxazolidin-2-one (3.80 g, 10.6 mmol) in ethanol (20 ml) was added 8N aqueous sodium hydroxide solution (3.96 ml, 31.7 mmol), and the mixture was stirred at 80° C. for 6 hrs. To the reaction solution was added water (20 ml) and the mixture was extracted with ethyl acetate (50 ml×2). The extract was washed with water and saturated brine, dried (anhydrous magnesium sulfate) and evaporated under reduced pressure. The residue was recrystallized from hexane-ethyl acetate to give the objective substance (2.67 g, 76%).

1. extractionthe mixture was extracted with ethyl acetate (50 ml×2)
2. washThe extract was washed with water and saturated brine
3. dry with materialdried (anhydrous magnesium sulfate)
4. customevaporated under reduced pressure
5. customThe residue was recrystallized from hexane-ethyl acetate
6. customto give the objective substance (2.67 g, 76%)