反应详情

To a solution of (4RS,5SR)-5-(4-fluorophenyl)-4-[3-(isopropyloxy)benzyl]-1,3-oxazolidin-2-one (5.85 g, 17.8 mmol) in ethanol (30 ml) was added 8N aqueous sodium hydroxide solution (8.9 ml, 71.0 mmol), and the mixture was heated under reflux for 5 hrs. The reaction solution-was concentrated under reduced pressure. To the solution was added water (100 ml) and the mixture was extracted with ethyl acetate (100 ml×2). The extract was washed with water, dried over anhydrous magnesium sulfate and evaporated under reduced pressure. The residue was crystallized from hexane-diethyl ether to give the objective substance (5.0 g, 93%).

1. temperaturethe mixture was heated
2. temperatureunder reflux for 5 hrs
3. concentrationThe reaction solution-was concentrated under reduced pressure
4. additionTo the solution was added water (100 ml)
5. extractionthe mixture was extracted with ethyl acetate (100 ml×2)
6. washThe extract was washed with water
7. dry with materialdried over anhydrous magnesium sulfate
8. customevaporated under reduced pressure
9. customThe residue was crystallized from hexane-diethyl ether
10. customto give the objective substance (5.0 g, 93%)