Sodium Hydroxide → HCID 22262206, compound

Participants

Reaction Steps

To a solution of (4RS,5SR)-4-[3-(tert-butyloxy)benzyl]-5-(4-fluorophenyl)-1,3-oxazolidin-2-one (6.6 g, 19.2 mmol) in ethanol (30 ml) was added 8N aqueous sodium hydroxide solution (9.6 ml, 76.9 mmol), and the mixture was heated under reflux for 4 hrs. The reaction solution was concentrated under reduced pressure. Water (150 ml) was added, and the mixture was extracted with ethyl acetate (200 ml). The extract was washed with water, dried over anhydrous magnesium sulfate and evaporated under reduced pressure. The residue was crystallized from hexane-diethyl ether to give the objective substance (5.86 g, 96%).

Provenance & Evidence