HCID 86593292, compound → HCID 22261471, compound

Participants

Reaction Steps

A solution of benzyl (2RS,3RS)-3-hydroxy-3-[4-(methoxycarbonyl)phenyl]-2-[3-(1,1,2,2-tetrafluoroethoxy)benzyl]propionate (69.90 g, 134.3 mmol) in ethanol (200 ml) was hydrogenated overnight using 10% palladium/carbon (containing water by 50%). (5 g) as a catalyst under normal pressure. The catalyst was removed by filtration, washed with ethanol, and the solvent of the recovered filtrate was evaporated under reduced pressure to give crude (2RS,3RS)-3-hydroxy-3-[4-(methoxycarbonyl)phenyl]-2-[3-(1,1,2,2-tetrafluoroethoxy)benzyl]propionic acid as a colorless foam.

Provenance & Evidence