Hydrochloric Acid → HCID 86593297, compound

Participants

Reaction Steps

While stirring zinc chloride (10.8 g, 79.0 mmol) in diethyl ether (50 ml), sodium borohydride (5.98 g, 158 mmol) was added at room temperature, and the mixture was stirred as it was for 2 hrs. The insoluble material in the mixture was removed by filtration and washed with diethyl ether to give a solution of zinc borohydride in diethyl ether. To the obtained solution was added a solution of ethyl 3-(6-chloropyridin-3-yl)-3-oxo-2-[3-(1,1,2,2-tetrafluoroethoxy)benzyl]propionate (17.14 g, 39.51 mmol) in diethyl ether (50 ml) under ice-cooling, and the mixture was stirred as it was for 20 min. To the reaction solution was added dilute hydrochloric acid by small portions to decompose excess zinc borohydride, and the mixture was extracted twice with ethyl acetate. The recovered organic layer was dried over anhydrous magnesium sulfate and the solvent was evaporated under reduced pressure. The obtained crude product was purified by silica gel column chromatography (hexane/ethyl acetate=3/1-2/1) to give the objective substance.

Provenance & Evidence