Potassium Carbonate → HCID 22261544, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of methyl 3-hydroxybenzoate (7.68 g, 50.5 mmol) in N,N-dimethylformamide (100 ml) were added potassium carbonate (13.96 g, 101 mmol) and neopentyl iodide (10 g, 50.5 mmol), and the mixture was stirred at 100° C. overnight. The mixture was diluted with ethyl acetate, water and saturated brine, dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (hexane:ethyl acetate=20:1, 10:1) to give methyl 3-(neopentyloxy)benzoate (4.69 g, 42%) as a colorless transparent oil.

Provenance & Evidence