HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 1-Benzyl-3-(chloromethyl)pyrrolidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | (1-Benzylpyrrolidin-3-yl)methanol | HCID 5176654 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | 1-Benzyl-3-(chloromethyl)pyrrolidine | HCID 12364518 | — |
Reaction Steps
To a refluxing solution of 15.3 g (0.08 mole) (3RS)-1-benzyl-3-hydroxymethylpyrrolidine in 220 ml CHCl3 was slowly added a solution of 330 ml thionyl chloride in 60 ml CHCl3, and the reflux was continued for one hour. The mixture was evaporated and the residue was dissolved in water.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06984627B1 |
| Source dataset | uspto-grants-2006_01 |
| ORD ID | ord-ed6dbfda700e48f385b89f859d909b15 |
| Source note | uspto-grants-2006_01 |