反应详情

5.7 g (21.7 mmol) of 3-cyanomethyl-1-benzhydryl azetidine was added slowly to a suspention of 2.9 g (76.0 mmol) of LiAlH4 in 80 mL of dry THF at roomtemperature. The reaction mixture was refluxed for 4 h. Excess hydride reagent was hydrolyzed by careful addition, with cooling, of NH4Cl(aq), the gelatinous mixture was filtered and the filter cake was washed repeatedly with THF. The solvent was evaporated, the residue was dissolved in diethyl ether, washed with brine and dried with Na2SO4. Evaporation of the solvent gave 5.0 g (87%) of the title compound.

1. temperatureThe reaction mixture was refluxed for 4 h
2. filtrationthe gelatinous mixture was filtered
3. washthe filter cake was washed repeatedly with THF
4. customThe solvent was evaporated
5. dissolutionthe residue was dissolved in diethyl ether
6. washwashed with brine
7. dry with materialdried with Na2SO4
8. customEvaporation of the solvent