Hydrochloric Acid → HCID 22258171, compound

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Reaction Steps

12.97 g crude compound of Example VII are refluxed 1.5 h in 200 ml concentrated hydrochloric acid. The mixture is cooled to rT and 200 mL water are added. The solution is extracted twice with toluene and the aqueous phase is concentrated under vacuum. The residue is stirred with ethanol, filtered, washed once with ethyl acetate and once with petrol ether and dried to yield 1.7 g (23% of th.) 2-(4,5-Dimethyl-1H-imidazol-2-yl)-1-(3-fluorophenyl)ethanone hydrochloride.

Provenance & Evidence