2,4-Difluorobenzoyl chloride → HCID 58582384, compound

Participants

Reaction Steps

380 mg (1.89 mmol) of 2,5,7-Trimethyl-4,5,6,7-tetrahydro-1H-benzimidazole hydrochloride (example X, step 3) is dissolved in 10 ml acetonitrile. 1.19 ml (8.52 mmol) TEA is added and the solution is cooled with an ice bath. 1.10 g (6.25 mmol) of 2,4-difluorobenzoyl chloride is dropped to the reaction mixture, which then is stirred at rt for 24 h. The solvent is evaporated and water is added to the crude. After it is stirred for a few minutes the water is decanted. This step is repeated twice. The crude is transferred to the next step (example 1, step 5).

Provenance & Evidence