HCID 58582384, compound → HCID 22258173, compound

Participants

Reaction Conditions

Reaction Steps

The compound of example X, step 4 is dissolved in 10 ml dioxane and 20 ml of hydrogen chloride solution (37%). The solution is heated at 100° C. for 20 h. The organic solvent is evaporated under vacuum. 30 ml water is added to the residue and the mixture is extracted with ethyl acetate. The water phase is reduced under vacuum. The residue is washed with sodium hydroxide solution to yield 150 mg (26.1% of th.) 1-(2,4-Difluoro-phenyl)-2-(4,6-dimethyl-4,5,6,7-tetrahydro-1H-benzimidazol-2-yl)ethanone.

Provenance & Evidence