Benzoyl chloride → HCID 22258292, compound

Participants

Reaction Steps

The compound is prepared as described in example X (step 4 and 5) with 1.00 g (8.05 mmol) 4-Ethyl-2,5-dimethyl-1H-imidazole (example XIII, step 1), 3.74 g (26.57 mmol) of benzoyl chloride and 2.85 g (28.18 mmol) of TEA in 20 ml acetonitrile. After reaction the solvent is evaporated under vacuum. The residue is extracted with toluene/water and the water phase is filtrated over a silica-layer. The solvent is evaporated under vacuum. The crude intermediate is directly transformed into 2-(4-Ethyl-5-methyl-1H-imidazol-2-yl)-1-phenylethanone hydrochloride. After the reaction the solvent is evaporated under vacuum. The residue is extracted with ethyl acetate/water. The water phase is concentrated.

Provenance & Evidence