HCID 178418361, compound → HCID 178432333, compound

Participants

Reaction Steps

20.0 g (0.137 mol) of 2,5-dimethyl-1H-benzimidazole are dissolved in 150 ml glacial acid and 2.50 g Pt-Mohr catalyst are added under argon. The solution is treated with hydrogen at 80° C. and at 3 bar pressure for 72 h. The solution is filtrated over celite and washed with glacial acid. The solvent is evaporated under vacuum and a few milliliters of water are added to the residue. Sodium hydrogen solution is added to a pH of 12-14. The mixture is extracted with ethyl acetate, the organic phase is extracted with water and dried over sodium sulfate. The ethyl acetate is evaporated under pressure and the residue is dissolved in a little bit of dichlormethane. Diethylether is added and the precipitate is filtrated and washed with diethylether to yield 1.0 g (4.87% of th.).

Provenance & Evidence