Methyl propiolate → HCID 9964732, compound

Participants

Reaction Steps

500 mg (2.25 mmol) of 2-(1H-Imidazol-2-yl)-1-phenylethanone hydrochloride (example L, step 1) are suspended in dichlormethane. Sodium hydrogen carbonate is added to the suspension and stirred for 1 h at rt. The suspension is filtrated and the solvent is evaporated under vacuum to yield the free base. The crude is dissolved in 3 ml methanol. 188.78 mg (2.25 mmol) of methyl propiolate are added dropwise to the solution. The mixture is stirred for 24 h at rt. The suspension is filtrated and the precipitate is washed with methanol and diethylether to yield 214 mg (40.0% of th.) 8-Benzoylimidazo[1,2-a]pyridin-5(1H)-one.

Provenance & Evidence