Methyl propiolate → HCID 22258204, compound

HRID 1610843Notes

Reaction equation

HRID 1610843 reaction equation
Cl.[CH3:2][C:3]1[N:4]=[C:5]([CH2:9][C:10]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([O:18][CH3:19])[CH:13]=2)=[O:11])[NH:6][C:7]=1[CH3:8].C[O-].[Na+].[C:23](OC)(=[O:26])[C:24]#[CH:25]>>[CH3:8][C:7]1[NH:6][C:5]2[N:4]([C:3]=1[CH3:2])[C:23](=[O:26])[CH:24]=[CH:25][C:9]=2[C:10](=[O:11])[C:12]1[CH:17]=[CH:16][CH:15]=[C:14]([O:18][CH3:19])[CH:13]=1

Participants

4

Reactant 3

HCID 13536Methyl propiolateHCID 10942334Sodium MethoxideHCID 22258305HCID 22258305, compound

Product 1

HCID 22258204HCID 22258204, compound

Procedure

The compound is prepared as described in example 20 with 55 mg (0.02 mmol) of 2-(4,5-Dimethyl-1H-imidazol-2-yl)-1-(3-methoxyphenyl)ethanone hydrochloride (example LV), 250 mg (4.62 mmol) of sodium methylate and 74 mg (0.89 mmol) methyl propiolate.

Workup

  1. customThe compound is prepared

Sources & evidence

ORD record
ord-5af5f641524743129779c45ddcdd98e8
Source dataset
uspto-grants-2006_01
Patent number
US06984646B2

Reaction notes

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