Methyl propiolate → HCID 22258209, compound

HRID 1610860Notes

Reaction equation

HRID 1610860 reaction equation
Cl.[CH2:2]([C:4]1[N:5]=[C:6]([CH2:10][C:11]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[O:12])[NH:7][C:8]=1[CH3:9])[CH3:3].C[O-].[Na+].[C:22](OC)(=[O:25])[C:23]#[CH:24]>>[C:11]([C:10]1[CH:24]=[CH:23][C:22](=[O:25])[N:7]2[C:8]([CH3:9])=[C:4]([CH2:2][CH3:3])[NH:5][C:6]=12)(=[O:12])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

Participants

4

Reactant 3

HCID 13536Methyl propiolateHCID 10942334Sodium MethoxideHCID 22258292HCID 22258292, compound

Product 1

HCID 22258209HCID 22258209, compound

Procedure

The compound is prepared as described in example 20 with 200 mg (0.76 mmol) of 2-(4-Ethyl-5-methyl-1H-imidazol-2-yl)-1-phenylethanone hydrochloride (example XVII), 50 mg (0.92 mmol) of sodium methylate and 63.5 mg (0.76 mmol) methyl propiolate.

Workup

  1. customThe compound is prepared

Sources & evidence

ORD record
ord-914139eb27964e43aa26c427709178e1
Source dataset
uspto-grants-2006_01
Patent number
US06984646B2

Reaction notes

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