Methyl propiolate → HCID 22258261, compound

HRID 1610861Notes

Reaction equation

HRID 1610861 reaction equation
Cl.[CH2:2]([C:4]1[N:5]=[C:6]([CH2:10][C:11]([C:13]2[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=2)=[O:12])[NH:7][C:8]=1[CH3:9])[CH3:3].C[O-].[Na+].[C:23](OC)(=[O:26])[C:24]#[CH:25]>>[CH2:2]([C:4]1[NH:5][C:6]2[N:7]([C:8]=1[CH3:9])[C:23](=[O:26])[CH:24]=[CH:25][C:10]=2[C:11](=[O:12])[C:13]1[CH:14]=[CH:15][C:16]([F:19])=[CH:17][CH:18]=1)[CH3:3]

Participants

4

Reactant 3

HCID 13536Methyl propiolateHCID 10942334Sodium MethoxideHCID 22258242HCID 22258242, compound

Product 1

HCID 22258261HCID 22258261, compound

Procedure

The compound is prepared as described in example 20 with 200 mg (0.71 mmol) of 2-(4-Ethyl-5-methyl-1H-imidazol-2-yl)-1-(4-fluorophenyl)ethanone hydrochloride (example XVIII), 50 mg (0.92 mmol) of sodium methylate and 59.5 mg (0.71 mmol) methyl propiolate.

Workup

  1. customThe compound is prepared

Sources & evidence

ORD record
ord-8b49c52c1a6840eba1b28d0af3b703b9
Source dataset
uspto-grants-2006_01
Patent number
US06984646B2

Reaction notes

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