Methyl propiolate → HCID 22258238, compound

HRID 1610862Notes

Reaction equation

HRID 1610862 reaction equation
Cl.[CH3:2][CH:3]1[C:11]2[N:10]=[C:9]([CH2:12][C:13]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)=[O:14])[NH:8][C:7]=2[CH2:6][CH2:5][CH2:4]1.C[O-].[Na+].[C:24](OC)(=[O:27])[C:25]#[CH:26]>>[C:13]([C:12]1[CH:26]=[CH:25][C:24](=[O:27])[N:8]2[C:7]3[CH2:6][CH2:5][CH2:4][CH:3]([CH3:2])[C:11]=3[NH:10][C:9]=12)(=[O:14])[C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1

Participants

4

Reactant 3

HCID 13536Methyl propiolateHCID 10942334Sodium MethoxideHCID 22258244HCID 22258244, compound

Product 1

HCID 22258238HCID 22258238, compound

Procedure

The compound is prepared as described in example 20 with 232 mg (0.80 mmol) of 2-(4-Methyl-4,5,6,7-tetrahydro-1H-benzimidazol-2-yl)-1-phenylethanone hydrochloride (example XIX), 50 mg (0.92 mmol) of sodium methylate and 67 mg (0.80 mmol) methyl propiolate.

Workup

  1. customThe compound is prepared

Sources & evidence

ORD record
ord-636906835b0048708a6e367db861026d
Source dataset
uspto-grants-2006_01
Patent number
US06984646B2

Reaction notes

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