Methyl propiolate → HCID 22258202, compound

HRID 1610863Notes

Reaction equation

HRID 1610863 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[C:9](=[O:20])[CH2:10][C:11]1[NH:15][C:14]2[CH2:16][CH2:17][CH2:18][CH2:19][C:13]=2[N:12]=1.C[O-].[Na+].[C:24](OC)(=[O:27])[C:25]#[CH:26]>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[C:9]([C:10]1[CH:26]=[CH:25][C:24](=[O:27])[N:15]2[C:14]3[CH2:16][CH2:17][CH2:18][CH2:19][C:13]=3[NH:12][C:11]=12)=[O:20]

Participants

4

Reactant 3

HCID 13536Methyl propiolateHCID 10942334Sodium MethoxideHCID 22258206HCID 22258206, compound

Product 1

HCID 22258202HCID 22258202, compound

Procedure

The compound is prepared as described in example 20 with 500 mg (1.81 mmol) of 1-(2,5-Difluorophenyl)-2-(4,5,6,7-tetrahydro-1H-benzimidazol-2-yl)ethanone (example XXXXII), 195.5 mg (3.62 mmol) of sodium methylate and 152.2 mg (1.81 mmol) methyl propiolate.

Workup

  1. customThe compound is prepared

Sources & evidence

ORD record
ord-0c8614d69a6142c58c8fbed80c83ba84
Source dataset
uspto-grants-2006_01
Patent number
US06984646B2

Reaction notes

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