Methyl propiolate → HCID 22258230, compound

HRID 1610864Notes

Reaction equation

HRID 1610864 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:19])[CH2:9][C:10]2[NH:14][C:13]3[CH2:15][CH2:16][CH2:17][CH2:18][C:12]=3[N:11]=2)=[CH:4][CH:3]=1.C[O-].[Na+].[C:23](OC)(=[O:26])[C:24]#[CH:25]>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:9]2[CH:25]=[CH:24][C:23](=[O:26])[N:14]3[C:13]4[CH2:15][CH2:16][CH2:17][CH2:18][C:12]=4[NH:11][C:10]=23)=[O:19])=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 13536Methyl propiolateHCID 10942334Sodium MethoxideHCID 22258224HCID 22258224, compound

Product 1

HCID 22258230HCID 22258230, compound

Procedure

The compound is prepared as described in example 20 with 500 mg (1.57 mmol) of 1-(4-Bromophenyl)-2-(4,5,6,7-tetrahydro-1H-benzimidazol-2-yl)ethanone (example XXXVI), 169.2 mg (3.13 mmol) of sodium methylate and 131.7 mg (1.57 mmol) methyl propiolate.

Workup

  1. customThe compound is prepared

Sources & evidence

ORD record
ord-05b980f4189c4c97bffa807418470544
Source dataset
uspto-grants-2006_01
Patent number
US06984646B2

Reaction notes

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