Methyl propiolate → HCID 22258266, compound

HRID 1610867Notes

Reaction equation

HRID 1610867 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:8](=[O:19])[CH2:9][C:10]2[NH:14][C:13]3[CH2:15][CH2:16][CH2:17][CH2:18][C:12]=3[N:11]=2)[CH:5]=[CH:6][CH:7]=1.C[O-].[Na+].[C:23](OC)(=[O:26])[C:24]#[CH:25]>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:5]=[CH:6][CH:7]=1)[C:8]([C:9]1[CH:25]=[CH:24][C:23](=[O:26])[N:14]2[C:13]3[CH2:15][CH2:16][CH2:17][CH2:18][C:12]=3[NH:11][C:10]=12)=[O:19]

Participants

4

Reactant 3

HCID 13536Methyl propiolateHCID 10942334Sodium MethoxideHCID 22258260HCID 22258260, compound

Product 1

HCID 22258266HCID 22258266, compound

Procedure

The compound is prepared as described in example 20 with 559.9 mg (2.03 mmol) of 1-(3-Chlorophenyl)-2-(4,5,6,7-tetrahydro-1H-benzimidazol-2-yl)ethanone (example XXXIX), 220.2 mg (4.08 mmol) of sodium methylate and 171.3 mg (2.03 mmol) methyl propiolate.

Workup

  1. customThe compound is prepared

Sources & evidence

ORD record
ord-6cbabfb1e73245baa74b260e88607506
Source dataset
uspto-grants-2006_01
Patent number
US06984646B2

Reaction notes

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