Methyl propiolate → HCID 22258280, compound

HRID 1610870Notes

Reaction equation

HRID 1610870 reaction equation
Cl.[CH3:2][C:3]1[NH:7][C:6]([CH2:8][C:9]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[O:10])=[N:5][C:4]=1[CH2:17][CH2:18][CH3:19].C[O-].[Na+].[C:23](OC)(=[O:26])[C:24]#[CH:25]>>[C:9]([C:8]1[CH:25]=[CH:24][C:23](=[O:26])[N:7]2[C:3]([CH3:2])=[C:4]([CH2:17][CH2:18][CH3:19])[NH:5][C:6]=12)(=[O:10])[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

Participants

4

Reactant 3

HCID 13536Methyl propiolateHCID 10942334Sodium MethoxideHCID 22258288HCID 22258288, compound

Product 1

HCID 22258280HCID 22258280, compound

Procedure

The compound is prepared as described in example 25 with 300 mg (1.08 mmol) of 2-(5-Methyl-4-propyl-1H-imidazol-2-yl)-1-phenylethanone hydrochloride (example XX), 60 mg (1.11 mmol) of sodium methylate and 90.5 mg (1.08 mmol) methyl propiolate.

Workup

  1. customThe compound is prepared

Sources & evidence

ORD record
ord-ecf6fb143d6b49d7899b8b4ee2155a2d
Source dataset
uspto-grants-2006_01
Patent number
US06984646B2

Reaction notes

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