Methyl propiolate → HCID 22258312, compound

HRID 1610871Notes

Reaction equation

HRID 1610871 reaction equation
Cl.[CH3:2][C:3]1[N:4]=[C:5]([CH2:9][C:10]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([CH3:18])[CH:13]=2)=[O:11])[NH:6][C:7]=1[CH3:8].C[O-].[Na+].[C:22](OC)(=[O:25])[C:23]#[CH:24]>>[CH3:8][C:7]1[NH:6][C:5]2[N:4]([C:3]=1[CH3:2])[C:22](=[O:25])[CH:23]=[CH:24][C:9]=2[C:10](=[O:11])[C:12]1[CH:17]=[CH:16][CH:15]=[C:14]([CH3:18])[CH:13]=1

Participants

4

Reactant 3

HCID 13536Methyl propiolateHCID 10942334Sodium MethoxideHCID 22258256HCID 22258256, compound

Product 1

HCID 22258312HCID 22258312, compound

Procedure

The compound is prepared as described in example 25 with 300 mg (1.13 mmol) of 2-(4,5-Dimethyl-1H-imidazol-2-yl)-1-(3-methylphenyl)ethanone hydrochloride (example XXII), 65 mg (1.20 mmol) of sodium methylate and 95.3 mg (1.13 mmol) methyl propiolate.

Workup

  1. customThe compound is prepared

Sources & evidence

ORD record
ord-1a7b2a4658d94fe7901e120917c753ff
Source dataset
uspto-grants-2006_01
Patent number
US06984646B2

Reaction notes

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