Methyl propiolate → HCID 22258162, compound

HRID 1610872Notes

Reaction equation

HRID 1610872 reaction equation
Cl.[F:2][C:3]1[CH:8]=[C:7]([F:9])[CH:6]=[CH:5][C:4]=1[C:10](=[O:19])[CH2:11][C:12]1[NH:13][C:14]([CH3:18])=[C:15]([CH3:17])[N:16]=1.C[O-].[Na+].[C:23](OC)(=[O:26])[C:24]#[CH:25]>>[F:2][C:3]1[CH:8]=[C:7]([F:9])[CH:6]=[CH:5][C:4]=1[C:10]([C:11]1[CH:25]=[CH:24][C:23](=[O:26])[N:16]2[C:15]([CH3:17])=[C:14]([CH3:18])[NH:13][C:12]=12)=[O:19]

Participants

4

Reactant 3

HCID 13536Methyl propiolateHCID 10942334Sodium MethoxideHCID 22258185HCID 22258185, compound

Product 1

HCID 22258162HCID 22258162, compound

Procedure

The compound is prepared as described in example 25 with 300 mg (1.05 mmol) of 2-(4,5-Dimethyl-1H-imidazol-2-yl)-1-(3-methylphenyl)ethanone hydrochloride (example XXIII), 65 mg (1.20 mmol) of sodium methylate and 88 mg (1.05 mmol) methyl propiolate.

Workup

  1. customThe compound is prepared

Sources & evidence

ORD record
ord-419ae19b7d114d22b4090dbd0c352c2c
Source dataset
uspto-grants-2006_01
Patent number
US06984646B2

Reaction notes

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