Methyl propiolate → HCID 22258211, compound

HRID 1610874Notes

Reaction equation

HRID 1610874 reaction equation
Cl.[CH3:2][C:3]1[CH:8]=[CH:7][C:6]([C:9](=[O:20])[CH2:10][C:11]2[NH:15][C:14]3[CH2:16][CH2:17][CH2:18][CH2:19][C:13]=3[N:12]=2)=[CH:5][CH:4]=1.C[O-].[Na+].[C:24](OC)(=[O:27])[C:25]#[CH:26]>>[CH3:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]([C:10]2[CH:26]=[CH:25][C:24](=[O:27])[N:15]3[C:14]4[CH2:16][CH2:17][CH2:18][CH2:19][C:13]=4[NH:12][C:11]=23)=[O:20])=[CH:5][CH:4]=1

Participants

4

Reactant 3

HCID 13536Methyl propiolateHCID 10942334Sodium MethoxideHCID 22258188HCID 22258188, compound

Product 1

HCID 22258211HCID 22258211, compound

Procedure

The compound is prepared as described in example 25 with 500 mg (1.49 mmol) of 1-(4-methylphenyl)-2-(4,5,6,7-tetrahydro-1H-benzimidazol-2-yl)ethanone hydrochloride (example IL), 160.7 mg (2.98 mmol) of sodium methylate and 125 mg (1.49 mmol) methyl propiolate.

Workup

  1. customThe compound is prepared

Sources & evidence

ORD record
ord-0fbaf7838cbe4160a980b9fd1e9c906e
Source dataset
uspto-grants-2006_01
Patent number
US06984646B2

Reaction notes

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